Genetic resistance against Fusarium Head Blight (FHB) in wheat is quantitative in nature, with over 550 quantitative trait loci (QTLs) identified for FHB severity and DON content. Despite extensive breeding efforts, achieving high levels of FHB resistance remains a significant challenge due to the impact of numerous small-effect QTLs. This study investigates alternative strategies for improving FHB resistance in wheat. We focused on 'Jagger', a hard red winter wheat cultivar, known for its high yield, and better quality but, inherent susceptibility to FHB. A forward genetic screen was performed on 840 M4 mutagenized lines derived from an EMS-mutagenized Jagger population across multiple years in field conditions, followed by confirmation under controlled environment conditions. Ten mutant lines consistently exhibited significantly lower FHB severity, with seven of these lines also showing significantly reduced DON levels. The identified resistant mutants were crossed with FHB-susceptible Jagger wild type to develop MutMap populations. Screening of the F2 population derived from one of the mutants (2020GH-271) identified an 8-10 Mb interval on the short arm of chromosome 2D associated with FHB resistance Future work is underway to fine-map the candidate region to support breeding efforts for improved FHB resistance.