We recently reported a fungal subtilase-type protease from Verticillium dahliae that cleaves a secreted defense protein called CRR1 in cotton. CRR1 contains two non-catalytic protein domains called DUF26 (domain of unknown function 26) and is implicated in defense against Verticillium wilt. DUF26 domains are associated with diverse proteins involved in defense. The fungal protease, which we called Vd-DUMP for V. dahliae DUF26 modifying protein, induces plant cell death when infiltrated into plant leaves. Here we report that Fusarium graminearum and Fusarium verticillioides, mycotoxin producing pathogens of wheat and corn, also secrete DUMPs. We also identify wheat protein TaCRR1 as a DUMP target.