Durum wheat (Triticum durum) is an important, high-value grain crop grown on approximately 1 million acres annually in North Dakota. Fusarium Head Blight is the most economically important pathogen in durum wheat production. Durum wheat lacks the genetic sources of resistance that have been found and successfully exploited in bread wheat (Triticum aestivum). With little genetic resistance available to exploit, combining the management strategies of variety selection and a post-anthesis fungicide application are currently the recommended best management practices for control of FHB. Studies were conducted in 2020-2023 under misted and dryland conditions at Langdon and Prosper, North Dakota, respectively using an RCB split-plot design with 3 replications. FHB incidence was higher under irrigated than dryland conditions and DON levels were also higher. Yield was not significantly impacted by the use of fungicide in any year of the study in Prosper but was higher with fungicide use than without at Langdon. DON levels in the grain were decreased with the use of fungicide in 1 of 4 years at Prosper and in 2 of 4 years at Langdon. Variety selection decreased DON accumulation in 2 of 4 years at Prosper and 2 of 4 years at Langdon. Of the 8 varieties tested, ND Grano and NDSU experimental line D111068 are showing less DON accumulation than known highly susceptible variety Mountrail and are ranking in the top half of varieties in terms of yield. ND Grano appears to be a good option in higher disease risk locations such as eastern North Dakota while the newer release ND Stanley may be better suited to lower disease risk locations in western North Dakota where its higher yields may be obtained with lower risk of high DON accumulation.