In conjunction with wheat breeders from the Great Plains and Eastern regions of the United States, we have assembled an association mapping panel of ~290 well-adapted cultivars and advanced breeding lines. This panel consists of mostly winter wheat varieties (both hard and soft), but also includes some spring and synthetic varieties. We sequenced this panel to ~15x coverage with wheat exome capture and used the genomic data to construct a wheat practical haplotype graph (PHG) representing the diversity in the panel. More than 1 million high quality segregating variants (MAF > 1%) were identified and combined with two years of field data measured at the Kansas State University FHB research station in Manhattan, Kansas. Initial GWAS results reveal ~50 significant associations across many wheat chromosomes for FHB severity, area under the disease progressive curve (AUDPC), FDK, and DON accumulation, including both known and novel regions for winter wheat associations. Validation of these associations is underway while we are waiting for a third year of field phenotypes. Descriptions of the panel makeup, PHG database construction, initial results, and how we as a community can use this data will be presented.