Hybrid wheat is considered as a key to yield boost, stability, climate resiliency, and enhanced biotic stress resistance. To understand the FHB resistance and heterosis in hybrid wheat, 1819 hybrid wheat along with 2167 inbred and parents and 53 commercial varieties were evaluated across three years (2019-2021) in corn spawn inoculated and misted FHB nursery in Nebraska. About 80% and 11% of the tested hybrids showed better resistance than susceptible and resistant check varieties, respectively. Similarly, 67% and 23% of inbred evaluated showed better resistance than susceptible and resistant check varieties, respectively. Mid-parent heterosis (MPH) for FHB index ranged from -74% to 154% with mean being -0.4%. Mean better parent heterosis (BPH) for FHB index was 11% ranging from -69% to 362%. MPH for FDK ranged from -47% to 66% with mean of 0.14%. Mean BPH was 9% ranging between -45%% and 101%. Anther exertion was negatively correlated with FHB index and significant in two of the three years tested. FDK was also negatively correlated with anther exertion but was significant only in 2021. Anthesis date was positively correlated with FHB index and negatively correlated with FDK. Results suggests hybrid wheat can be alternative for increased FHB resistance in wheat.